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Age at onset in Huntington's disease: Replication study on the association of HAP1

✍ Scribed by Georgia Karadima; Christina Dimovasili; Georgios Koutsis; Demetris Vassilopoulos; Marios Panas


Book ID
119343076
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
103 KB
Volume
18
Category
Article
ISSN
1353-8020

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## Abstract In transgenic mouse models of Huntington disease (HD) environmental enrichment significantly delays disease onset. A questionnaire‐based survey of 154 adults with diagnosed HD (mean 4.2 years postdiagnosis) and a known __IT15__ CAG repeat length, explored whether premorbid lifestyle may