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A Genome Scan for Modifiers of Age at Onset in Huntington Disease: The HD MAPS Study

✍ Scribed by Jian-Liang Li; Michael R. Hayden; Elisabeth W. Almqvist; Ryan R. Brinkman; Alexandra Durr; Catherine Dodé; Patrick J. Morrison; Oksana Suchowersky; Christopher A. Ross; Russell L. Margolis; Adam Rosenblatt; Estrella Gómez-Tortosa; David Mayo Cabrero; Andrea Novelletto; Marina Frontali; Martha Nance; Ronald J.A. Trent; Elizabeth McCusker; Randi Jones; Jane S. Paulsen; Madeline Harrison; Andrea Zanko; Ruth K. Abramson; Ana L. Russ; Beth Knowlton; Luc Djoussé; Jayalakshmi S. Mysore; Suzanne Tariot; Michael F. Gusella; Vanessa C. Wheeler; Larry D. Atwood; L. Adrienne Cupples; Marie Saint-Hilaire; Jang-Ho J. Cha; Steven M. Hersch; Walter J. Koroshetz; James F. Gusella; Marcy E. MacDonald; Richard H. Myers


Book ID
117854287
Publisher
American Society of Human Genetics
Year
2003
Tongue
English
Weight
593 KB
Volume
73
Category
Article
ISSN
0002-9297

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## Abstract The age of onset of Huntington's disease (HD) is inversely correlated with the CAG length in the HD gene. The CAG repeat length accounts for 70% of the variability in HD age of onset. However, 90% of individuals worldwide with expanded alleles possess between 40 and 50 CAG repeat length