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Affinity modulation of the α2 integrin I domain

✍ Scribed by S. Dickeson; T.P. Stricker; A.L. Benton; Y. Pan; S.A. Santoro


Book ID
116729479
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
58 KB
Volume
25
Category
Article
ISSN
0945-053X

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## Abstract Three divalent cation binding sites in the integrin β I domain have been shown to regulate ligand binding and adhesion. However, the degree of ligand binding and adhesion varies among integrins. The αLβ2 and α4β7 integrins show an increase in ligand binding affinity and adhesion when on