Crystal structure of the α1β1 integrin I-domain: insights into integrin I-domain function
✍ Scribed by Matthias Nolte; R.Blake Pepinsky; Sergei Yu. Venyaminov; Victor Koteliansky; Philip J. Gotwals; Michael Karpusas
- Book ID
- 117110964
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 772 KB
- Volume
- 452
- Category
- Article
- ISSN
- 0014-5793
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📜 SIMILAR VOLUMES
Adhesion to collagens by most cell types is mediated by the integrins a1b1 and a2b1. Both integrin a subunits belong to a group which is characterized by the presence of an I domain in the N-terminal half of the molecule, and this domain has been implicated in the ligand recognition. Since purified
## Abstract The I domain of integrin αE was modeled on the crystal structure of that in CD11b and mutated to produce an open (high affinity) or closed (low affinity) conformation. K562 transfectants expressing mutant αE and wild‐type β7 were tested for adhesion to E‐cadherin‐Fc. Downward displaceme