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Protein Kinase D1 and the β1 Integrin Cytoplasmic Domain Control β1 Integrin Function via Regulation of Rap1 Activation

✍ Scribed by Ricardo B. Medeiros; Deborah M. Dickey; Heekyoung Chung; Angie C. Quale; Lakshmi R. Nagarajan; Daniel D. Billadeau; Yoji Shimizu


Book ID
116570479
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
866 KB
Volume
23
Category
Article
ISSN
1074-7613

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Rap1 controls activation of the αMβ2 int
✍ Jenson Lim; Aurélien G. Dupuy; David R. Critchley; Emmanuelle Caron 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 386 KB

The small GTPase Rap1 and the cytoskeletal protein talin regulate binding of C3bi-opsonised red blood cells (RBC) to integrin a M b 2 in phagocytic cells, although the mechanism has not been investigated. Using COS-7 cells transfected with a M b 2 , we show that Rap1 acts on the b 2 and not the a M