Assignments of human integrin α1I domain in theapoand Mg2+bound states
✍ Scribed by Yanni K.-Y. Chin, Stephen Headey, Biswaranjan Mohanty…
- Book ID
- 120903187
- Publisher
- Springer-Verlag
- Year
- 2013
- Tongue
- English
- Weight
- 496 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1874-2718
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📜 SIMILAR VOLUMES
Adhesion to collagens by most cell types is mediated by the integrins a1b1 and a2b1. Both integrin a subunits belong to a group which is characterized by the presence of an I domain in the N-terminal half of the molecule, and this domain has been implicated in the ligand recognition. Since purified
## Abstract The authors have previously demonstrated that α~2~β~1~ integrin‐mediated pancreatic cancer cell adhesion to Type I collagen is Mg^2+^‐dependent, inhibited by Ca^2+^, and that this integrin, purified from cell lysates using Type I‐collagen‐sepharose in Mg^2+^, can be eluted with Ca^2+^.