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Affected sib pair method for searching major gene in multifactorial disease

โœ Scribed by Norikazu Yasuda; Takehiko Sasazuki

Book ID
105393760
Publisher
Nature Publishing Group
Year
1982
Tongue
English
Weight
844 KB
Volume
27
Category
Article
ISSN
1435-232X

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For complex genetic diseases involving incomplete penetrance, genetic heterogeneity, and multiple disease genes, it is often difficult to determine the molecular variant(s) responsible for the disease pathogenesis. Linkage and association studies may help identify genetic regions and molecular varia