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Aerosol matrix-assisted laser desorption ionization mass spectrometry

✍ Scribed by Kermit K. Murray; David H. Russell

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
996 KB
Volume
5
Category
Article
ISSN
1044-0305

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✦ Synopsis

A new method of liquid sample introduction for a time-of-flight mass spectrometer (TOF-MS) has been developed by applying the method of matrix-assisted laser desorption ionization to aerosols. Analyte biomolecules are dissolved in a methanol solvent along with a UVabsorbing matrix and formed into an aerosol with a pneumatic nebulizer. The aerosol particles are dried in a heated skimmer tube before ionization by pulsed 355-nm UV laser radiation. Mass analysis is achieved in a linear TOF-MS. Results for the ionization of bovine insulin (5733.5 Mw) are reported.

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