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Aerosol Matrix-assisted Laser Desorption/Ionization Mass Spectrometry: I.—Effect of Solvent on Ion Signal

✍ Scribed by Russell, David H.; Beeson, Michelle D.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
837 KB
Volume
31
Category
Article
ISSN
1076-5174

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✦ Synopsis

The effects of methanol, ethanol, propan-2-01 and acetonitrile on the aerosol matrix-assisted laser desorptionlionization (MALDI) ion signal of hradykinin, bovine insulin and myoglobin were examined. The effect of these solvents mixed with water was also studied. The aerosol MALDI ion signal for each analyte depends on the solvent, but the solvent dependence is different for the matrices 4-nitroaniline and a-cyano-4-hydroxycinnamic acid. The data suggest that matrix-analyte-solvent interactions are an important consideration for the aerosol MALDI ion signal. It appears that the ion signal is the result of a competition between solvent polarity and volatility. The solvent polarity affects matrix-analyte interactions whereas solvent volatility affects the aerosol drying process.

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