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Advances in the use of recombinant baculoviruses for the expression of heterologous proteins

โœ Scribed by Anthony H Davies


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
591 KB
Volume
6
Category
Article
ISSN
0958-1669

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โœฆ Synopsis


Recombinant baculoviruses are widely used to express heterologous proteins. They are particularly useful for the high-level expression of eukaryotic proteins with fastidious co-or post-translational processing requirements. The recent publication of the Autographa californica nuclear polyhedrosis virus (AcNPV) genome will greatly increase the sophistication of baculovirus molecular biology. Recently, this has been accompanied by the first applications of virion display technology to AcNPV, increased use of promoters other than that of the polyhedrin gene, and insight into the interplay between the authenticity of glycosylation of recombinant proteins and their functionality.


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