## Abstract Adsorption of albumin, γ‐globulin, and fibrinogen from solution, under both static and flow conditions, onto several hydrophobic polymers was studied using internal reflection infrared spectroscopy. Isotherm curves experimentally found were consistant with Langmuir type adsorption. The
Adsorption of plasma proteins in solution to uncharged, hydrophobic polymer surfaces
✍ Scribed by Brash, J. L. ;Lyman, D. J.
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 651 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
Infrared internal reflection spectroscopy has been used to study the adsorption of certain plasma proteins on a variety of hydrophobic polymer surfaces. The behavior of the systems studied was almost identical. Under static conditions the proteins appear to be rapidly adsorbed as monomolecular layers from solutions varying in concentration between a few me-% and normal plasma levels. These monolayers are deduced to be closely packed arrays in which the protein molecules appear to retain their native globular form. The bearing of these results on the mechanism of surface-induced coagulation is significant.
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