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Adsorption of plasma proteins in solution to uncharged, hydrophobic polymer surfaces

✍ Scribed by Brash, J. L. ;Lyman, D. J.


Publisher
John Wiley and Sons
Year
1969
Tongue
English
Weight
651 KB
Volume
3
Category
Article
ISSN
0021-9304

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✦ Synopsis


Infrared internal reflection spectroscopy has been used to study the adsorption of certain plasma proteins on a variety of hydrophobic polymer surfaces. The behavior of the systems studied was almost identical. Under static conditions the proteins appear to be rapidly adsorbed as monomolecular layers from solutions varying in concentration between a few me-% and normal plasma levels. These monolayers are deduced to be closely packed arrays in which the protein molecules appear to retain their native globular form. The bearing of these results on the mechanism of surface-induced coagulation is significant.


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