Adriamycin in localized and metastatic uterine sarcomas
โ Scribed by M. Steven Piver; Joseph J. Barlow; Shashikant B. Lele; Roberto Yazigi
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 166 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0022-4790
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Various drug combinations including Adriamycin have been tested in soft tissue sarcomas, but optimal treatment remains unclear. We have evaluated Adriamycin with and without dimethyl-triazeno-imidazole-carboxamide (DTIC) in the treatment of Stage III or IV and recurrent sarcomas of the uterus. Two h
Intensive chemotherapy with high-dose cyclophosphamide and adriamycin with DTIC maintenance was given to 12 patients with metastatic soft tissue sarcomas. A partial response rate of 25% was seen; this is no better than can be achieved with single-agent therapy. Because of substantial toxicity withou