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Adrenergic stimulation of osteoclastogenesis mediated by expression of osteoclast differentiation factor in MC3T3-E1 osteoblast-like cells

✍ Scribed by Toshimitsu Takeuchi; Takahiro Tsuboi; Michitsugu Arai; Akifumi Togari

Book ID
113992561
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
568 KB
Volume
61
Category
Article
ISSN
0006-2952

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## Abstract Statins inhibit 3‐hydroxy‐3‐methylglutaryl‐coenzyme A (HMG‐CoA) reductase, which catalyzes conversion of HMG‐CoA to mevalonate, a rate‐limiting step in cholesterol synthesis. The present study was undertaken to understand the events of osteoblast differentiation induced by statins. Simv