✦ LIBER ✦

Adoption studies of schizophrenia

✍ Scribed by Ingraham, Loring J.; Kety, Seymour S.

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 8 KB
Volume: 97
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(200021)97:1<18::aid-ajmg4>3.0.co;2-l

No coin nor oath required. For personal study only.

✦ Synopsis

The observation that schizophrenia is more commonly observed among the relatives of individuals with schizophrenia than in the general population does not indicate the mechanism that produces such familiality occurs. Adoption designs permit evaluation of the role of genetic factors in schizophrenia independently of the influence of family environments. Results from studies of adoptees with schizophrenia and their biological and adoptive relatives indicate that genetic factors play a highly significant role in the risk for schizophrenia. This genetically mediated risk to relatives includes an increased prevalence of both schizophrenia and a nonpsychotic syndrome analogous to schizophrenia, but does not represent a general liability to other forms of psychopathology. Although adoption studies have convincingly demonstrated an important role for genetic factors in schizophrenia, the necessity and specificity of such factors, their precise identity, and their interaction with environmental influences remain unknown.

📜 SIMILAR VOLUMES

Linkage and associated studies of schizo

Linkage and associated studies of schizophrenia

✍ Riley, Brien P.; McGuffin, Peter 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB 👁 2 views

Genetic epidemiology has provided consistent evidence over many years that schizophrenia has a genetic component, and that this genetic component is complex, polygenic, and involves epistatic interaction between loci. Molecular genetics studies have, however, so far failed to identify any DNA varian

Association study of schizophrenia among

Association study of schizophrenia among Indian families

✍ Prasad, S.; Deshpande, S.N.; Bhatia, T.; Wood, J.; Nimgaonkar, V.L.; Thelma, B.K 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 9 KB 👁 2 views

A putative association of schizophrenia with a Msc I restriction fragment length polymorphism at the dopamine D3 receptor gene locus (DRD3) was tested among Indian families, using haplotype relative risk analysis and the transmission disequilibrium test (n=66 families and 58 sets of transmissions, r

Association study of a polymorphism of n

Association study of a polymorphism of nonerythroid ?-spectrin gene with schizophrenia

✍ Murakami, Naoya; Kitamura, Noboru; Kajimoto, Yasuo; Hashimoto, Takeshi; Yasuda, 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 7 KB 👁 2 views

The specificity of cytoarchitectural abnormalities in limbic structures of patients with schizophrenia and their contributions towards the etiology of schizophrenia remain unknown. We have recently reported an increased breakdown of nonerythroid ␣-spectrin (fodrin), a major component of neuronal cyt

Pharmacogenetics of schizophrenia

✍ Cichon, Sven; N�then, Markus M.; Rietschel, Marcella; Propping, Peter 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 43 KB 👁 1 views

Patients display significant differences in response to therapeutic agents which may be caused by a variety of factors. Among them, genetic components presumably play a major role. Pharmacogenetics is the field of research that attempts to unravel the relationship between genetic variation affecting

Genetic epidemiological study of schizop

Genetic epidemiological study of schizophrenia in Palau, Micronesia: Prevalence and familiality

✍ Myles-Worsley, Marina; Coon, Hilary; Tiobech, Josepha; Collier, Jay; Dale, Paul; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 45 KB 👁 2 views

We are studying the genetic etiology of schizophrenia in the Republic of Palau, a remote island nation in Micronesia that has been geographically and ethnically isolated for approximately 2,000 years. The first epidemiological phase sought to estimate the lifetime prevalence of schizophrenia and eva

Association study of the 5-HT6 receptor

Association study of the 5-HT6 receptor gene in schizophrenia

✍ Shinkai, Takahiro; Ohmori, Osamu; Kojima, Hideki; Terao, Takeshi; Suzuki, Takash 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 7 KB 👁 2 views

Serotonergic (5-hydroxytryptamine; 5-HT) transmission may play an important role in the treatment and/or pathogenesis of schizophrenia. Previous studies reported that several atypical antipsychotic agents have high affinities for the 5-HT 6 receptor. The 5-HT 6 receptor gene polymorphism might contr