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Adjuvant methotrexate-5-fluorouracil for extracapsular squamous cell carcinoma in cervical metastasis

✍ Scribed by Jonas T. Johnson; Eugene N. Myers; Barbara A. Sigler; Robin L. Wagner; David G. Mayernik; Teresa A. Nolan


Book ID
115043431
Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
266 KB
Volume
100
Category
Article
ISSN
0023-852X

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Background. Prognosis of head and neck squamous cell carcinoma (HNSCC) is strongly associated with cervical lymph node metastasis. Cathepsin-D is a lysosomal protease expressed in all cells. Its role in extracellular matrix degradation is postulated to promote tumor invasion and metastasis. Increase