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Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma

✍ Scribed by Ternovoi, Vladimir V; Curiel, David T; Smith, Bruce F; Siegal, Gene P


Book ID
109886065
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
272 KB
Volume
86
Category
Article
ISSN
0023-6837

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Transgenic mice deficient for the p53 gene were reported to frequently develop angiosarcoma (AS), suggesting that alterations in the gene are associated with tumorigenesis of AS. However, little is known about genetic changes, including p53 gene alterations, in human AS because of its rarity. We ana