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Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: sensitization to cisplatin and doxorubicin

โœ Scribed by Ganjavi, H; Gee, M; Narendran, A; Parkinson, N; Krishnamoorthy, M; Freedman, M H; Malkin, D


Book ID
110019309
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
185 KB
Volume
13
Category
Article
ISSN
0929-1903

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We investigated the therapeutic potential and molecular mechanism of adenovirus-mediated wt p53 gene therapy for drug-resistant human bladder cancers. KK47, a human bladder-cancer cell line, along with the drug-resistant sublines KK47/DDP10, KK47/DDP20 (cisplatin-resistant) and KK47/ ADM (doxorubici