Adenosine deaminase inhibitors: synthesis and structure-activity relationships of 2-hydroxy-3-nonyl derivatives of azoles
โ Scribed by Cristalli, Gloria; Eleuteri, Alessandra; Volpini, Rosaria; Vittori, Sauro; Camaioni, Emido; Lupidi, Giulio
- Book ID
- 125960281
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 650 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0022-2623
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Adenosine deaminase (ADA) is the enzyme which catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. It is widely distributed in vertebrate tissues and i s thought to be essential for proper functioning of mammalian cells. ADA inhibitors may
## Synthesis, Diastereoisomeric Resolution and Biological Activity of 1-(2-Hydroxy-3-nonyl)-1,2,4triazole-3-carboxamide. -The synthesis and diastereomeric resolution of the title carboxamides, which are good inhibitors of adenosine deaminase, is described. The erythro isomer (VIII) proves to be m