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Additive inhibitory effects of bromocryptine (CB-154) and medroxyprogesterone acetate (MPA) on dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in the rat

✍ Scribed by Dauvois, Sophie; Spinola, Paulo G.; Labrie, Fernand


Book ID
121931292
Publisher
Elsevier Science
Year
1989
Weight
835 KB
Volume
25
Category
Article
ISSN
0277-5379

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The novel anti-estrogen EM-800 and medroxyprogesterone acetate (MPA) inhibit estrone (E 1 )-stimulated growth of dimethylbenz[a]anthracene (DMBA)-induced mammary tumors in a rat model. After 65 days, ovariectomy (OVX) decreased total tumor area to 9.6 ؎ 3.9% of initial size, while E 1 (1.0 ¡g, s.c.,