Additive Effects of 5-Aza-2’-deoxycytidine and Irradiation on Clonogenic Survival of Human Medulloblastoma Cell Lines
✍ Scribed by Ina Patties; Jutta Jahns; Guido Hildebrandt; Rolf-Dieter Kortmann; Annegret Glasow
- Publisher
- Springer
- Year
- 2009
- Tongue
- German
- Weight
- 361 KB
- Volume
- 185
- Category
- Article
- ISSN
- 0179-7158
No coin nor oath required. For personal study only.
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## Abstract During tumorigenesis, cancer‐related genes can be silenced by aberrant DNA methylation and by changes in chromatin structure. It has been reported that 5‐aza‐2′‐deoxycytidine, a potent inhibitor of DNA methylation, in combination with histone deacetylase inhibitors, can produce a synerg