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Effect of histone deacetylase inhibitor LAQ824 on antineoplastic action of 5-Aza-2′-deoxycytidine (decitabine) on human breast carcinoma cells

✍ Scribed by Annie Hurtubise; Richard L. Momparler


Publisher
Springer
Year
2006
Tongue
English
Weight
549 KB
Volume
58
Category
Article
ISSN
0344-5704

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Synergistic antineoplastic action of DNA
✍ Mélanie Primeau; Jacynthe Gagnon; Richard L. Momparler 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 233 KB

## Abstract During tumorigenesis, cancer‐related genes can be silenced by aberrant DNA methylation and by changes in chromatin structure. It has been reported that 5‐aza‐2′‐deoxycytidine, a potent inhibitor of DNA methylation, in combination with histone deacetylase inhibitors, can produce a synerg