Addition of Trimethylsilyl Enol Ethers to Quinolinium Salts: A Facile Synthesis of Methyl 2-(2-Oxoalkyl)-1,2-dihydroquinoline-1-carboxylates and Their Cyclization
โ Scribed by Akiba, Kinya; Akiba, Kin-ya; Kobayashi, Toshifumi; Yamamoto, Yohsuke
- Book ID
- 121876245
- Publisher
- Japan Institute of Heterocyclic Chemistry
- Year
- 1984
- Tongue
- English
- Weight
- 99 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0385-5414
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
An efficient method to synthesize 1-P-keto substituted 2-ethoxycarbonyl ( or 2-acetyl )-1, 2-dihydroisoquinolines (A) is described, utilizing boron enolates and isoquinolinium salts. The products were treated with sodium ethoxide to afford
Titanium enolates add to the 4-position of l-phenoxycarbonylpyridinium salts to give 1,4\_dihydropyridines; subsequent aromatization provides 4-(2-oxoalkyl)pyridines. Development of practical methods for directing nucleophiles to the 4-position of a pyridine ring has been a challenge to synthetic ch