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Regioselective addition of titanium enolates to 1-acylpyridinium salts. A convenient synthesis of 4-(2-oxoalkyl)pyridines

โœ Scribed by Daniel L. Comins; Jack D. Brown

Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
180 KB
Volume
25
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Titanium enolates add to the 4-position of l-phenoxycarbonylpyridinium salts to give 1,4_dihydropyridines; subsequent aromatization provides 4-(2-oxoalkyl)pyridines. Development of practical methods for directing nucleophiles to the 4-position of a pyridine ring has been a challenge to synthetic chemists for many years. We and the research groups of Lylel, Piers2, Katritzky3, and Akiba4 have made recent

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