Regioselective addition of titanium enol
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Daniel L. Comins; Jack D. Brown
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Article
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1984
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Elsevier Science
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French
β 180 KB
Titanium enolates add to the 4-position of l-phenoxycarbonylpyridinium salts to give 1,4\_dihydropyridines; subsequent aromatization provides 4-(2-oxoalkyl)pyridines. Development of practical methods for directing nucleophiles to the 4-position of a pyridine ring has been a challenge to synthetic ch