Addition of amino esters to thiiranium ion intermediates: A novel approach to the synthesis of new potential aminopeptidase inhibitors
β Scribed by Duncan M. Gill; Neil A. Pegg; Christopher M. Rayner
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 280 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
The catalytic and asymmetric nitro-Mannich reaction of nitro compounds to Ξ±-imino esters catalyzed by chiral bisoxazoline-copper complexes [Eq. (1); Pg = protecting group] gave Ξ²-nitro-Ξ±-amino esters with excellent diastereo- and enantioselectivities. The reactions can be performed under ambient con
The development of CΓC bond-forming reactions that create two new stereogenic centers with high diastereo-and enantioselectivity in a single step can open new routes to highly valuable optically active compounds. The catalytic enantioselective addition to imines [1] belongs to this class of importan