𝔖 Bobbio Scriptorium
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Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA

✍ Scribed by KARRAN, PETER; LINDAHL, TOMAS; GRIFFIN, BEVERLY


Book ID
109714465
Publisher
Nature Publishing Group
Year
1979
Tongue
English
Weight
252 KB
Volume
280
Category
Article
ISSN
0028-0836

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The DNA-repair protein O 6 -methylguanine-DNA methyltransferase (alkyltransferase; MGMT) is a major determinant of resistance of cells to various alkylating cytostatic drugs. Its expression in tissues is highly variable, indicating complex regulatory mechanisms involved. Transfection-mediated expres