## Abstract The DNA repair protein __O__^6^βmethylguanineβDNA methyltransferase (MGMT) has been implicated in resistance of human brain tumors to alkylating agents. We observed that 14 human medulloblastomaβ and gliomaderived cell lines differ in sensitivity to the methylating agent __N__βmethylβ__
β¦ LIBER β¦
Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA
β Scribed by KARRAN, PETER; LINDAHL, TOMAS; GRIFFIN, BEVERLY
- Book ID
- 109714465
- Publisher
- Nature Publishing Group
- Year
- 1979
- Tongue
- English
- Weight
- 252 KB
- Volume
- 280
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/280076a0
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The DNA-repair protein O 6 -methylguanine-DNA methyltransferase (alkyltransferase; MGMT) is a major determinant of resistance of cells to various alkylating cytostatic drugs. Its expression in tissues is highly variable, indicating complex regulatory mechanisms involved. Transfection-mediated expres