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Adaptive regulation of neutral amino acid transport system A in rat H4 hepatoma cells

✍ Scribed by Michael S. Kilberg; He-Ping Han; Ellen F. Barber; Thomas C. Chiles

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 889 KB
Volume: 122
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041220219

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✦ Synopsis

Substrate regulation of System A transport activity in rat H4 hepatoma cells is described. The uptake of several amino acids was tested in t h e presence of system-specific inhibitors. System A activity was increased in a RNA-and protein synthesis-dependent manner by amino acid deprivation of the cells (adaptive regulation), whereas transport by Systems ASC, N, y + , and L was

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