Cytoskeletal-dependent activation of system A for neutral amino acid transport in osmotically stressed mammalian cells: A role for system A in the intracellular accumulation of osmolytes

System a neutral amino acid transporter

System a neutral amino acid transporter regulation by interleukin-1β in human osteoarthritic synovial cells: evidence for involvement of prostaglandin E2 as a second messenger

✍ Valérie Le Maire; Egle Solito; Françoise Russo-Marie; Alain Hernvann; Hervé Le M 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 275 KB 👁 1 views

We studied the long-terms effects of interleukin-1beta (IL-1beta; 3 to 6 h) on alpha-(methylamino) isobutyric acid (MeAIB), a nonmetabolizable amino acid transported by system A. We found that IL-1beta induced a large decrease in MeAIB uptake by human osteoarthritic synovial cells and a concomitant