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Adaptation to culture of human embryonic stem cells and oncogenesis in vivo

✍ Scribed by Baker, Duncan E C; Harrison, Neil J; Maltby, Edna; Smith, Kath; Moore, Harry D; Shaw, Pamela J; Heath, Paul R; Holden, Hazel; Andrews, Peter W

Book ID
109909727
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
325 KB
Volume
25
Category
Article
ISSN
1087-0156

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## Abstract Human embryonic stem cells (hESCs) during long‐term culture acquire chromosomal changes similar to those occurring in tumorigenesis. This was raised concerns about the progression from hESCs to malignant cells. This study aimed to investigate the changes in chromosomes, cell phenotype,