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Adaptation in cyclic AMP signalling processes: A central role for cyclic AMP phosphodiesterases

✍ Scribed by Miles D. Houslay

Book ID
115647374
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
114 KB
Volume
9
Category
Article
ISSN
1084-9521

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A new method for assay of cyclic AMP phosphodiesterase (EC 3.1.4.17) has been developed based on the observation that a mixture of cyclic AMP and AMP can be resolved on a column of florisil (activated magnesium silicate) at pH 7.0. The cyclic nucleotide is retained by the silicate and the AMP which