𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Adaptation de methodes classiques a la synthese de glycerophospholipides marques au carbone 14

✍ Scribed by J. L. Dana; L. Pichat

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
525 KB
Volume
18
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Classical phospholipids syntheses were selected and adapted to the preparation of natural glycerophospholipids labelled with carbon 14 in the acyl moiety. 1,2‐(^14^C) diacyl‐3‐bromo sn‐glycerol was the starting material.

Saturated ^14^C‐phosphatidyl‐ethanolamine, choline and serine were obtained in 30 %, 25 % and 11 % yields relative to the ^14^C‐fatty acid, by condensation of a suitably protected amino‐alcohol with a (^14^C‐diacyl) phosphatidic acid in presence of triisopropyl‐benzenesulfonyl‐chloride followed by deprotection of the amino group.

The synthesis of unsaturated (or mixed) ^14^C phosphatidyl ethanolamine was achieved, with a 28 % yield, by condensation of the ^14^C‐diacyl‐bromoglycerol with the silver salt of the N‐trityl aminoethyl and benzyl diester of phosphoric acid and subsequent deprotections.

📜 SIMILAR VOLUMES

Synthese d'une serie de calix[8]arenes m
Synthese d'une serie de calix[8]arenes marques au carbone 14
✍ C. Montagne-Marcellin; M. Archimbaud; E. Ansoborlo; H. J. Cristau 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 263 KB

## Abstract This paper describes syntheses of paratertiobutyl calix[8]arene, calix[8]arene, and parasulfonic calix[8]arene acid, labelled with ^14^C on the methylene position. Parasulfonic calix[8]arene acid when injected to rats, allowed to know the hydrosoluble calixarenes distribution in organis

Syntheses de Glycerides Marques au Carbo
Syntheses de Glycerides Marques au Carbone 14
✍ J. L. Danan; L. Pichat 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 342 KB

Starting from 1-2 isopropylidene sn-glycerol, the synthesis o f mono and diglycerides labelled with 14C i n the a c y l moiety has been achieved. ## The acyl chloride method was found t o be the best one f o r the e s t e r i f i c a t i o n step. The various methods, here proposed with p a h i t

Nouvelle methode de synthese des princip
Nouvelle methode de synthese des principaux metabolites des catecholamines marques au carbone 14
✍ Louis Pichat; Jean Tostain 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 French ⚖ 742 KB

## Abstract Methylsulfinylcarbanion used in large excess reacts with methyl (carboxyl ^14^C) vanillate **2** a, methyl (carboxyl ^14^C) isovanillate **2** b and methyl 3,4 dibenzyloxy (carboxyl ^14^C) benzoate **2** d to give 90 % yields of β‐ketosulfoxides **3** a, **3** b, **3** d. Submitted to t

Synthese De Phospholipides Marques Au Ca
Synthese De Phospholipides Marques Au Carbone 14 A l'aide Du “pyrophosphate D'Enediol Cyclique”
✍ J.-L. Danan; L. Pichat 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 287 KB

## Abstract ^14^C labelled phospholipid synthesis through the use of “cyclic enediolpyrophosphate”. Ramirez's phrophosphate **1** was used in a one pot convenient synthesis of a few [1‐^14^C]‐acyl phospholipids. Reagent **1** was condensed with 1,2‐[1‐^14^C] dipalmitoyl Sn‐glycerol to the cyclic t

Une nouvelle synthèse des cyanures alcal
Une nouvelle synthèse des cyanures alcalins marqués au carbone -14 par pyrolyse de la cyanamide de baryum en présence de sodium et d'oxyde de titane
✍ P. Vercier 📂 Article 📅 1968 🏛 John Wiley and Sons 🌐 French ⚖ 199 KB 👁 1 views

Une nouvelle synthkse des cyanures alcalins marquks au carbone -14 par pyrolyse de la cyanamide de baryum en presence de sodium et d'oxyde de titane R e p le 26 fevrier 1968 Au cours de la 2e Conference Internationale sur la PrCparation des Molicules MarquCes (l), nous avons mentionne une nouvelle m

Synthese de l'acide (chloro-3 cyclohexyl
Synthese de l'acide (chloro-3 cyclohexyl-4 phenyl)-4 oxo-4 butyrique (804 CB) marque au carbone 14
✍ L. Pichat; J. P. Beaucourt; M. Herbert; F. Krausz; J. C. Breliere 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 287 KB

## Abstract The Grignard reagent made from p‐cyclohexyl m‐chloroiodobenzene is carbonated with ^14^CO~2~ to give 3‐chloro 4‐cyclohexyl benzoǐc acid (radioactive yield 50 %). This acid is transformed into the corresponding chloride with thionyl chloride. Condensation of the chloride with tris‐(trime