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Synthese De Phospholipides Marques Au Carbone 14 A l'aide Du “pyrophosphate D'Enediol Cyclique”

✍ Scribed by J.-L. Danan; L. Pichat

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
287 KB
Volume
17
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

^14^C labelled phospholipid synthesis through the use of “cyclic enediolpyrophosphate”.

Ramirez's phrophosphate 1 was used in a one pot convenient synthesis of a few [1‐^14^C]‐acyl phospholipids. Reagent 1 was condensed with 1,2‐[1‐^14^C] dipalmitoyl Sn‐glycerol to the cyclic triester phosphate 4 which without isolation, was reacted with N‐tritylethanolamine, 3‐0‐benzyl Sn‐glycerol and glycerol leading to intermediates 5, 6, 7 which were deprotected by triethylamine hydrolysis and other appropriate treatments.

📜 SIMILAR VOLUMES

Adaptation de methodes classiques a la s
Adaptation de methodes classiques a la synthese de glycerophospholipides marques au carbone 14
✍ J. L. Dana; L. Pichat 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 525 KB

## Abstract Classical phospholipids syntheses were selected and adapted to the preparation of natural glycerophospholipids labelled with carbon 14 in the acyl moiety. 1,2‐(^14^C) diacyl‐3‐bromo sn‐glycerol was the starting material. Saturated ^14^C‐phosphatidyl‐ethanolamine, choline and serine wer