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Synthese de l'acide (chloro-3 cyclohexyl-4 phenyl)-4 oxo-4 butyrique (804 CB) marque au carbone 14

✍ Scribed by L. Pichat; J. P. Beaucourt; M. Herbert; F. Krausz; J. C. Breliere

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
287 KB
Volume
12
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The Grignard reagent made from p‐cyclohexyl m‐chloroiodobenzene is carbonated with ^14^CO~2~ to give 3‐chloro 4‐cyclohexyl benzoǐc acid (radioactive yield 50 %). This acid is transformed into the corresponding chloride with thionyl chloride. Condensation of the chloride with tris‐(trimethylsilyl) 1‐lithio‐1,1,2 ethane tricarboxylate gives after hydrolysis 4‐(3‐chloro 4‐cyclohexyl phenyl) 4‐oxobutyric acid 4‐^14^C with an overall yield of 41 % based on barium carbonate. (Specific activity : 53 mCi/mMole).

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