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Acute myelogenous leukemia in a patient with Li–Fraumeni syndrome treated with valproic acid, theophyllamine and all-trans retinoic acid: a case report

✍ Scribed by Ånensen, N; Skavland, J; Stapnes, C; Ryningen, A; Børresen-Dale, A-L; Gjertsen, B T; Bruserud, Ø


Book ID
110056638
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
119 KB
Volume
20
Category
Article
ISSN
0887-6924

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Clinical trial of valproic acid and all-
✍ Gesine Bug; Markus Ritter; Barbara Wassmann; Claudia Schoch; Thorsten Heinzel; K 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 275 KB 👁 2 views

## Abstract ## BACKGROUND Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, induced in vitro differentiation of primary acute myeloid leukemia (AML) blasts, an effect enhanced by all‐trans retinoic acid (ATRA). Clinical responses to VPA were recently observed in patients with myelodyspl