## Abstract ## BACKGROUND Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, induced in vitro differentiation of primary acute myeloid leukemia (AML) blasts, an effect enhanced by allβtrans retinoic acid (ATRA). Clinical responses to VPA were recently observed in patients with myelodyspl
β¦ LIBER β¦
Increase in platelet count in older, poor-risk patients with acute myeloid leukemia or myelodysplastic syndrome treated with valproic acid and all-trans retinoic acid
β Scribed by Chiara Pilatrino; Daniela Cilloni; Emanuela Messa; Alessandro Morotti; Emilia Giugliano; Marisa Pautasso; Ubaldo Familiari; Susanna Cappia; Pier Giuseppe Pelicci; Francesco Lo Coco; Giuseppe Saglio; Angelo Guerrasio
- Book ID
- 102804444
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 772 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0008-543X
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## Abstract ## BACKGROUND Valproic acid (VPA) inhibits histone deacetylase activity and, synergizing with allβtrans retinoic acid (ATRA), achieves differentiation induction of myeloid blast cells in vitro. ## METHODS We used VPA in 58 patients with acute myeloid leukemia (AML) who were too old a
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