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Increase in platelet count in older, poor-risk patients with acute myeloid leukemia or myelodysplastic syndrome treated with valproic acid and all-trans retinoic acid

✍ Scribed by Chiara Pilatrino; Daniela Cilloni; Emanuela Messa; Alessandro Morotti; Emilia Giugliano; Marisa Pautasso; Ubaldo Familiari; Susanna Cappia; Pier Giuseppe Pelicci; Francesco Lo Coco; Giuseppe Saglio; Angelo Guerrasio


Book ID
102804444
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
772 KB
Volume
104
Category
Article
ISSN
0008-543X

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## Abstract ## BACKGROUND Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, induced in vitro differentiation of primary acute myeloid leukemia (AML) blasts, an effect enhanced by all‐trans retinoic acid (ATRA). Clinical responses to VPA were recently observed in patients with myelodyspl

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## Abstract ## BACKGROUND Valproic acid (VPA) inhibits histone deacetylase activity and, synergizing with all‐trans retinoic acid (ATRA), achieves differentiation induction of myeloid blast cells in vitro. ## METHODS We used VPA in 58 patients with acute myeloid leukemia (AML) who were too old a