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Acute megakaryoblastic leukemia with translocation t(1;22)(p13;q13) in a 10-week-old infant

โœ Scribed by Setsuko Washio; Masaru Ido; Eiich Azuma; Masako Fukui; Takeo Shibata; Shao-Li Zhang; Yoshihiro Komada; Masahiro Ito; Tadashi Koike; Yasuhiko Kaneko; Minoru Sakurai

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
545 KB
Volume
39
Category
Article
ISSN
0361-8609

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โœฆ Synopsis

A 1 O-week-old girl without Down syndrome developed an acute megakaryoblastic leukemia (AMKL). Bone marrow aspirates and biopsy showed megakaryoblastic infiltration with myelofibrosis. The diagnosis was made based on the findings that the positive reactions of leukemic cells to platelet peroxidase and to monoclonal antibodies which recognize platelet-specific surface glycoprotein (GP) Ilb/llla and GP78. The blasts also showed myeloid and monocytoid differentiation antigens. The leukemic cells had a karyotype of 46,XX,t(1;22)(~13;q13). Our case and two other infantile cases reported by other investigators establish the novel association of the t(l;22) with AMKL.

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