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t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia

✍ Scribed by José L. Vizmanos; María J. Larráyoz; Idoya Lahortiga; Filomena Floristán; Carmen Álvarez; María D. Odero; Francisco J. Novo; María J. Calasanz

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
159 KB
Volume
36
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

Recently, it was shown that t(10;16)(q22;p13) fuses the MORF and CREBBP genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the MORF‐CREBBP fusion in an 84‐year‐old patient diagnosed with AML M5b, in which the t(10;16)(q22;p13) was the only cytogenetic aberration. This supports that this is a recurrent pathogenic translocation in AML. © 2003 Wiley‐Liss, Inc.

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