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Acute lymphblastic leukemia in adult identical twins

✍ Scribed by Hecht, Th. ;Henke, M. ;Schempp, W. ;Bross, K. J. ;L�hr, G. W.

Book ID
104721042
Publisher
Springer-Verlag
Year
1988
Weight
781 KB
Volume
56
Category
Article
ISSN
1432-0584

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✦ Synopsis

The development of acute lymphoblastic leukemia (c-ALL) in identical twins is reported. The first born had ALL in 1982 and bone marrow transplantation was performed in first complete remission (CR) from his healthy twin-brother the same year. The bone marrow donor developed ALL in 1985; he received an autologous bone marrow transplantation in first CR in 1986. Unfortunately, both patients relapsed in 1986. Cytogenetic studies of the first born revealed multiple chromosomal abnormalities and a marker chromosome whereas the second patient had a Philadelphia chromosome. Genetic reasons or exposure to leukemogenic agents may be responsible for the onset of these leukemias.

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✍ Eugene B. Rosenberg; Ronald B. Herberman; Paul H. Levine; Roger H. Halterman; Ja 📂 Article 📅 1972 🏛 John Wiley and Sons 🌐 French ⚖ 700 KB

## Abstract Cellular cytotoxicity reactions to human leukemia cells were measured with a sensitive, quantitative assay of cell‐mediated immunity. Freshly explanted leukemia cells, rather than tissue culture cells, were tested to ensure that the antigens detected were not acquired in vitro. Identica