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Acute effects of FK506 and cyclosporine A on cultured human proximal tubular cells

โœ Scribed by Blaehr, Hanne; Andersen, Claus B.; Ladefoged, Joergen

Book ID
123338941
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
569 KB
Volume
228
Category
Article
ISSN
0926-6917

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## Abstract Cyclosporine A (CsA) is known to have direct toxicity to renal tubular cells. Its toxicity may be mediated by intracellular calcium because CsA increases intracellular calcium concentration and enhances the activities of calciumโ€dependent calpains and caspases. Calbindinโ€D~28k~, a cytos