Cytosolic proteins that specifically bind cyclosporine A and FK-506 were isolated and purified from the JURKAT human T-helper cell line. These binding proteins were purified by affinity, molecular weight exclusion and weak cation exchange column chromatography. Radiolabeled cyclosporine A specifical
Effects of FK-506 and cyclosporine on human T and B lymphoproliferative responses
✍ Scribed by M. Wa̧sik; B. Stȩpień-Sopniewska; Z. Łagodziński; A. Górski
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 312 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0162-3109
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## Abstract The effects of the immunosuppressants cyclosporin A (CsA), FK506 and rapamycin have been compared using murine B cells activated with a variety of mitogens. FK506 is a macrolide antibiotic that has been recently shown to inhibit T cell activation by a mechanism that appears similar to t
Lymphoproliferative disorders (LPDs) are a serious side effect of immunosuppression after liver transplantation, and the introduction on the market of a new immunosuppressive drug has been associated with an increased risk of these disorders. To compare the effect of cyclosporine A (CSA) and FK506 i