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Comparison of effects of cyclosporine A in renal proximal tubular cell line and primary cultures of rat and human

✍ Scribed by Mariano Aguilar; Ursula Schramm

Book ID
119538900
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
118 KB
Volume
88
Category
Article
ISSN
0378-4274

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Effect of calbindin-D28K on cyclosporine
Effect of calbindin-D28K on cyclosporine toxicity in cultured renal proximal tubular cells
✍ Ming-Ju Wu; Li-Wen Lai; Yeong-Hau H. Lien πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 118 KB

## Abstract Cyclosporine A (CsA) is known to have direct toxicity to renal tubular cells. Its toxicity may be mediated by intracellular calcium because CsA increases intracellular calcium concentration and enhances the activities of calcium‐dependent calpains and caspases. Calbindin‐D~28k~, a cytos