Active and passive experimental autoimmune encephalomyelitis in strain 129/J (H-2b) mice

✍ Scribed by R.B. Fritz; M.-L. Zhao

• Book ID: 101244375
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 397 KB
• Volume: 45
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/(sici)1097-4547(19960815)45:4<471::aid-jnr17>3.0.co;2-3

✦ Synopsis

Failure of C57BLhJ and C57BL/10Sn (H-zb) mice to exhibit clinical signs of experimental autoimmune encephalomyelitis following immunization with myelin basic protein (MBP) has been interpreted to indicate that mice of this haplotype are resistant to E M . Recently, we immunized strain 12915 (H-2b) mice with rat MBP and found that clinical signs of EAE were expressed in the majority of animals within 2 to 3 weeks. Passive EAE was readily induced by adoptive transfer of MBP-specific T cell lines to syngeneic recipients. MBP peptide 89-101 and PLP peptide 178-191 induced EAE upon active immunization although proteolipid protein peptide 139-151 was ineffective in this regard. Strain 129/J mice never recovered fully from acute EAE, and signs of relapsing disease were not observed. 0 1996 Wiley-Liss, Inc.