Increased demyelination and axonal damage in metallothionein I+II-deficient mice during experimental autoimmune encephalomyelitis

Treatment with metallothionein prevents

Treatment with metallothionein prevents demyelination and axonal damage and increases oligodendrocyte precursors and tissue repair during experimental autoimmune encephalomyelitis

✍ Milena Penkowa; Juan Hidalgo 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 859 KB

Experimental autoimmune encephalomyelitis (EAE) is an animal model for the human demyelinating disease multiple sclerosis (MS). EAE and MS are characterized by significant inflammation, demyelination, neuroglial damage, and cell death. Metallothionein‐I and ‐II (MT‐I + II) are antiinflammatory and n