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Activation of the Xmrk proto-oncogene of Xiphophorus by overexpression and mutational alterations

✍ Scribed by Dimitrijevic, Nicola; Winkler, Christoph; Wellbrock, Claudia; Gómez, Ana; Duschl, Jutta; Altschmied, Joachim; Schartl, Manfred

Book ID: 110061231
Publisher: Nature Publishing Group
Year: 1998
Tongue: English
Weight: 678 KB
Volume: 16
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1201693

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## Abstract The mutagenicity of oxygen free radicals was studied in a forward mutation system. pEC plasmid containing the human c‐Ha‐__ras__‐1 proto‐oncogene was reacted with oxygen free radicals generated by Cu^2+^ and H~2~O~2~ and was then transfected into NIH/3T3 cells. Transformed foci were obs