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Constitutive Activation and Specific Signaling of the Xmrk Receptor in Xiphophorus melanoma

✍ Scribed by Ana Gómez,Claudia Wellbrock,Manfred Schartl


Book ID
126340857
Publisher
Springer
Year
2002
Tongue
English
Weight
179 KB
Volume
4
Category
Article
ISSN
1053-6426

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## Abstract Mutated versions or overexpression of receptor tyrosine kinases such as the epidermal growth factor receptor are found frequently in various cancers. In Xiphophorus the formation of hereditary melanoma is caused by the overexpression of the __Xmrk__ oncogene locus. Xmrk is a mutationall