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Constitutive Activation of the Mitogen-Activated Protein Kinase Signaling Pathway in Acral Melanomas

✍ Scribed by Takata, Minoru ;Goto, Yasufumi ;Ichii, Nami ;Yamaura, Maki ;Murata, Hiroshi ;Koga, Hiroshi ;Fujimoto, Akihide ;Saida, Toshiaki


Book ID
110733560
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
863 KB
Volume
125
Category
Article
ISSN
0022-202X

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## Abstract We studied the effect of prolonged activation of mitogen‐activated protein kinase (MAPK) signaling on 1,25 dihydroxyvitamin D (1,25(OH)~2~D~3~) action in the immortalized human prostate epithelial cell line RWPE1 and its Ki‐Ras transformed clone RWPE2. 1,25(OH)~2~D~3~‐treatment caused g