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Amplification of the Proto-neu Oncogene Facilitates Oncogenic Activation by a Single Point Mutation

✍ Scribed by Mien-Chie Hung, Duen-Hwa Yan and Xiaoyan Zhao

Book ID
123636934
Publisher
National Academy of Sciences
Year
1989
Tongue
English
Weight
927 KB
Volume
86
Category
Article
ISSN
0027-8424

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## Abstract The mutagenicity of oxygen free radicals was studied in a forward mutation system. pEC plasmid containing the human c‐Ha‐__ras__‐1 proto‐oncogene was reacted with oxygen free radicals generated by Cu^2+^ and H~2~O~2~ and was then transfected into NIH/3T3 cells. Transformed foci were obs