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Activation of the arachidonic acid cascade by interleukin-1 in human chondrocytes

✍ Scribed by I. Knott; M. Dieu; A. Houbion; J. Remacle; M. Raes


Publisher
SP Birkhäuser Verlag Basel
Year
1994
Tongue
English
Weight
204 KB
Volume
41
Category
Article
ISSN
1420-908X

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## Abstract Interleukin‐1 induces release of NO and PGE~2~ and production of matrix degrading enzymes in chondrocytes. In osteoarthritis (OA), IL‐1 continually, or episodically, acts on chondrocytes in a paracrine and autocrine manner. Human chondrocytes in chondron pellet culture were treated chro