Notch-1 regulates Akt signaling pathway
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Dongmei Guo; Jingjing Ye; Jianjian Dai; Lizhen Li; Feng Chen; Daoxin Ma; Chunyan
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Article
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2009
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Elsevier Science
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English
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Gain-of-function mutations in Notch-1 are common in T-cell lymphoblastic leukemia (T-ALL), making this receptor a promising target for drugs such as gamma-secretase inhibitors (GSIs). However, GSIs seem to be active in only a small fraction of T-ALL cell lines with constitutive Notch-1 activity and