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Roles of the ERK, JNK/AP-1/cyclin D1–CDK4 pathway in silica-induced cell cycle changes in human embryo lung fibroblast cells

✍ Scribed by Jia, Xiaowei; Liu, Bingci; Shi, Xianglin; Ye, Meng; Zhang, Fengmei; Liu, Haifeng


Book ID
119739721
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
393 KB
Volume
35
Category
Article
ISSN
1065-6995

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Exposure to silica is associated with progressive pulmonary inflammation and fibrosis. Our previous study had demonstrated silica exposure could cause cell cycle alternation and activator protein-1 (AP-1) activation. This study showed that silica exposure induced phosphorylation of p70S6 kinase (p70